CP Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3|3 A2
Cellular Component:  anchored component of plasma membrane; extracellular region; extracellular space; plasma membrane
Molecular Function:  chaperone binding; copper ion binding; ferroxidase activity; metal ion binding; oxidoreductase activity
Biological Process:  cellular iron ion homeostasis; copper ion transport; ion transport; iron ion homeostasis; iron ion transport; oxidation-reduction process; response to copper ion
Reference #:  Q61147 (UniProtKB)
Alt. Names/Synonyms: CERU; Ceruloplasmin; Cp; D3Ertd555e; Ferroxidase; OTTMUSP00000027617
Gene Symbols: Cp
Molecular weight: 121,151 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
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CP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene