CP Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Belongs to the multicopper oxidase family. Expressed by the liver and secreted in plasma. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3|3 A2
Cellular Component:  anchored component of plasma membrane; extracellular region; extracellular space; plasma membrane
Molecular Function:  chaperone binding; copper ion binding; ferroxidase activity; metal ion binding; oxidoreductase activity
Biological Process:  cellular iron ion homeostasis; copper ion transport; ion transport; iron ion homeostasis; iron ion transport; oxidation-reduction process; response to copper ion
Reference #:  Q61147 (UniProtKB)
Alt. Names/Synonyms: CERU; Ceruloplasmin; Cp; D3Ertd555; D3Ertd555e; Ferroxidase; OTTMUSP00000027617
Gene Symbols: Cp
Molecular weight: 121,151 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
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CP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene