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CP
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Belongs to the multicopper oxidase family. Expressed by the liver and secreted in plasma. Note: This description may include information from UniProtKB.
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| Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 3q24-q25.1 |
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Cellular Component:
endoplasmic reticulum lumen; extracellular region; extracellular space; plasma membrane
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Molecular Function:
copper ion binding; ferroxidase activity; oxidoreductase activity; protein-folding chaperone binding
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Biological Process:
copper ion transport; intracellular iron ion homeostasis; iron ion transport
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Disease: Aceruloplasminemia
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Reference #:
P00450
(UniProtKB)
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Alt. Names/Synonyms: CERU; Ceruloplasmin; ceruloplasmin (ferroxidase); CP; CP-2; Ferroxidase
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Gene Symbols: CP
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Molecular weight:
122,219 Da
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Basal Isoelectric point:
5.44
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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