CP Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q24-q25.1
Cellular Component:  endoplasmic reticulum lumen; extracellular region; extracellular space
Molecular Function:  chaperone binding; copper ion binding; ferroxidase activity
Biological Process:  cellular iron ion homeostasis; cellular protein metabolic process; copper ion transport; oxidation-reduction process; post-translational protein modification
Disease: Aceruloplasminemia
Reference #:  P00450 (UniProtKB)
Alt. Names/Synonyms: CERU; Ceruloplasmin; ceruloplasmin (ferroxidase); CP; CP-2; Ferroxidase
Gene Symbols: CP
Molecular weight: 122,205 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CP

Protein Structure Not Found.


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