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Claudin-15
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. Belongs to the claudin family. Detected in colon (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 5|5 G2 |
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Cellular Component:
anchoring junction; bicellular tight junction; lateral plasma membrane; membrane; plasma membrane
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Molecular Function:
structural molecule activity
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Biological Process:
bicellular tight junction assembly; cell adhesion; monoatomic ion transport
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Reference #:
Q9Z0S5
(UniProtKB)
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Alt. Names/Synonyms: 2210009B08Rik; BB107105; claudin 15; Claudin-15; claudin15; CLD15; Cldn15; OTTMUSP00000027347
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Gene Symbols: Cldn15
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Molecular weight:
24,280 Da
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Basal Isoelectric point:
7.48
Predict pI for various phosphorylation states
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