CEP135 Involved in early centriole assembly/duplication/biogenesis/formation/. Required for centriole elongation. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Belongs to the CEP135/TSGA10 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 4q12
Cellular Component:  centriole; centrosome; cytosol
Molecular Function:  protein binding; protein C-terminus binding
Biological Process:  centriole replication; centriole-centriole cohesion; ciliary basal body-plasma membrane docking; G2/M transition of mitotic cell cycle; positive regulation of establishment of protein localization; positive regulation of non-motile cilium assembly; regulation of G2/M transition of mitotic cell cycle
Disease: Microcephaly 8, Primary, Autosomal Recessive
Reference #:  Q66GS9 (UniProtKB)
Alt. Names/Synonyms: centrosomal protein 135kDa; Centrosomal protein 4; Centrosomal protein of 135 kDa; centrosome protein cep135; CEP135; CEP4; CP135; KIAA0635
Gene Symbols: CEP135
Molecular weight: 133,490 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below

CEP135

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB