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CCTA
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Belongs to the TCP-1 chaperonin family. Note: This description may include information from UniProtKB.
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| Protein type: Chaperone; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 17 A1|17 8.72 cM |
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Cellular Component:
acrosomal vesicle; cell body; centrosome; chaperonin-containing T-complex; cytoplasm; cytoskeleton; Golgi apparatus; heterochromatin; microtubule; microtubule organizing center; pericentriolar material; zona pellucida receptor complex
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Molecular Function:
ATP binding; ATP hydrolysis activity; ATP-dependent protein folding chaperone; nucleotide binding; protein binding; protein folding chaperone; ubiquitin protein ligase binding; unfolded protein binding
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Biological Process:
binding of sperm to zona pellucida; chaperone-mediated protein folding; positive regulation of establishment of protein localization to telomere; positive regulation of telomerase activity; positive regulation of telomerase RNA localization to Cajal body; positive regulation of telomere maintenance via telomerase; protein folding; protein stabilization; scaRNA localization to Cajal body
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Reference #:
P11983
(UniProtKB)
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Alt. Names/Synonyms: AI528772; c-c; c-cpn; CCT; CCT-alpha; Cct1; Ccta; p63; t-complex polypeptide 1; t-complex protein 1; T-complex protein 1 subunit alpha; T-complex protein 1 subunit alpha A; T-complex protein 1 subunit alpha B; Tailless complex polypeptide 1A; Tailless complex polypeptide 1B; Tcp-; Tcp-1; TCP-1-A; TCP-1-alpha; TCP-1-B; Tcp1; TCPA; Tp6; Tp63; TRic
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Gene Symbols: Tcp1
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Molecular weight:
60,449 Da
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Basal Isoelectric point:
5.82
Predict pI for various phosphorylation states
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