CAPZB F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Belongs to the F-actin-capping protein beta subunit family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4 D3|4 70.59 cM
Cellular Component:  asymmetric synapse; brush border; cortical cytoskeleton; cytoplasm; cytoskeleton; dendritic spine; F-actin capping protein complex; hippocampal mossy fiber to CA3 synapse; intercalated disc; lamellipodium; membrane; neuronal cell body; postsynaptic density; Schaffer collateral - CA1 synapse; WASH complex; Z disc
Molecular Function:  actin binding; actin filament binding; beta-tubulin binding; protein binding
Biological Process:  actin cytoskeleton organization; actin filament capping; barbed-end actin filament capping; cell morphogenesis; cell projection organization; cytoskeleton organization; lamellipodium assembly; muscle fiber development; negative regulation of filopodium assembly; negative regulation of microtubule polymerization; neuron projection development; regulation of cell morphogenesis; regulation of lamellipodium assembly; regulation of protein kinase C signaling
Reference #:  P47757 (UniProtKB)
Alt. Names/Synonyms: 1700120C01Rik; AI325129; Cap; Cappb1; capping protein (actin filament) muscle Z-line, beta; capping protein beta 1; CapZ beta; Capzb; CPB; CPB1; CPB2; CPbeat2; CPbet; CPbeta1; CPbeta2; F-actin-capping protein subunit beta; OTTMUSP00000010479; OTTMUSP00000010480
Gene Symbols: Capzb
Molecular weight: 31,345 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene