CAPZB F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Belongs to the F-actin-capping protein beta subunit family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component:  actin cytoskeleton; cytoskeleton; cytosol; sarcomere; WASH complex
Molecular Function:  actin binding; protein binding
Biological Process:  actin cytoskeleton organization; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; cytoskeleton organization; ER to Golgi vesicle-mediated transport; regulation of cell morphogenesis
Reference #:  P47756 (UniProtKB)
Alt. Names/Synonyms: Cap Z; CAPB; CAPPB; capping protein (actin filament) muscle Z-line, beta; CAPZ; CapZ beta; CAPZB; F-actin capping protein beta subunit; F-actin-capping protein subunit beta; MGC104401; MGC129749; MGC129750
Gene Symbols: CAPZB
Molecular weight: 31,350 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
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Protein Structure Not Found.

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