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BSN
Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts. At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis. Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5. Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import. Exclusively expressed in brain. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of mouse Ortholog: 9 F1|9 59.07 cM |
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Cellular Component:
axon; axon cytoplasm; cell cortex; cell projection; cell surface; cochlear hair cell ribbon synapse; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytoskeleton of presynaptic active zone; cytosol; dendrite; excitatory synapse; extrinsic component of membrane; GABA-ergic synapse; glutamatergic synapse; Golgi-associated vesicle; hippocampal mossy fiber to CA3 synapse; inhibitory synapse; membrane; neuron projection terminus; neuronal cell body; piccolo-bassoon transport vesicle; postsynaptic density; presynapse; presynaptic active zone; presynaptic active zone cytoplasmic component; ribbon synapse; Schaffer collateral - CA1 synapse; synapse; synaptic membrane; synaptic vesicle; trans-Golgi network
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Molecular Function:
dynein light chain binding; metal ion binding; protein binding; structural constituent of presynaptic active zone; transcription corepressor binding
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Biological Process:
axo-dendritic transport; presynapse to nucleus signaling pathway; presynaptic active zone assembly; protein localization to synapse; regulation of synaptic vesicle cycle; regulation of ubiquitin protein ligase activity; retrograde axonal transport; synapse organization; synaptic vesicle clustering
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Reference #:
O88737
(UniProtKB)
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Alt. Names/Synonyms: bassoon; Bsn; Kiaa0434; OTTMUSP00000018359; presynaptic cytomatrix protein; Protein bassoon
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Gene Symbols: Bsn
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Molecular weight:
418,843 Da
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Basal Isoelectric point:
7.62
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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