BSN Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts. At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis. Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5. Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import. Exclusively expressed in brain. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  axon; cell junction; cell surface; cytoskeleton of presynaptic active zone; dendrite; excitatory synapse; GABA-ergic synapse; glutamatergic synapse; neuron projection terminus; nucleus; postsynaptic density; presynaptic active zone; Schaffer collateral - CA1 synapse; synaptic vesicle; synaptic vesicle membrane
Molecular Function:  metal ion binding; structural constituent of presynaptic active zone
Biological Process:  chemical synaptic transmission; maintenance of presynaptic active zone structure; presynapse to nucleus signaling pathway; protein localization to synapse; regulation of synaptic vesicle cycle; synapse assembly
Reference #:  Q9UPA5 (UniProtKB)
Alt. Names/Synonyms: bassoon (presynaptic cytomatrix protein); bassoon presynaptic cytomatrix protein; BSN; KIAA0434; neuronal double zinc finger protein; Protein bassoon; Zinc finger protein 231; ZNF231
Gene Symbols: BSN
Molecular weight: 416,469 Da
Basal Isoelectric point: 7.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene