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AZIN1
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily. Expressed in liver. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor |
| Chromosomal Location of human Ortholog: 8q22.3 |
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Cellular Component:
cytoplasm; cytosol; nucleus
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Molecular Function:
ornithine decarboxylase activator activity; ornithine decarboxylase activity; protein binding
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Biological Process:
negative regulation of protein catabolic process; positive regulation of polyamine transmembrane transport; putrescine biosynthetic process from ornithine
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Reference #:
O14977
(UniProtKB)
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Alt. Names/Synonyms: Antizyme inhibitor 1; AZI; AZI1; AZIA1; AZIN1; MGC3832; MGC691; OAZI; OAZIN; ODC1L; ornithine decarboxylase 1-like; Ornithine decarboxylase antizyme inhibitor
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Gene Symbols: AZIN1
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Molecular weight:
49,535 Da
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Basal Isoelectric point:
4.66
Predict pI for various phosphorylation states
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