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ASB4
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. Belongs to the ankyrin SOCS box (ASB) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 7q21.3 |
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Cellular Component:
Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cytosol
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Molecular Function:
ubiquitin protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
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Biological Process:
intracellular signal transduction; positive regulation of vasculogenesis; protein autoubiquitination
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Reference #:
Q9Y574
(UniProtKB)
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Alt. Names/Synonyms: ankyrin repeat and SOCS box containing 4; Ankyrin repeat and SOCS box protein 4; ankyrin repeat and SOCS box-containing 4; ASB-4; ASB4; MGC142039; MGC142041
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Gene Symbols: ASB4
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Molecular weight:
48,195 Da
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Basal Isoelectric point:
7.57
Predict pI for various phosphorylation states
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