ASB4 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. Belongs to the ankyrin SOCS box (ASB) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 7q21.3
Cellular Component:  Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cytosol
Molecular Function:  ubiquitin protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
Biological Process:  intracellular signal transduction; positive regulation of vasculogenesis; protein autoubiquitination
Reference #:  Q9Y574 (UniProtKB)
Alt. Names/Synonyms: ankyrin repeat and SOCS box containing 4; Ankyrin repeat and SOCS box protein 4; ankyrin repeat and SOCS box-containing 4; ASB-4; ASB4; MGC142039; MGC142041
Gene Symbols: ASB4
Molecular weight: 48,195 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Select Structure to View Below

ASB4

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene