ARHGAP6 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: X|X F5
Cellular Component:  actin cytoskeleton; cytoplasm
Molecular Function:  GTPase activator activity; phospholipase activator activity; phospholipase binding; SH3 domain binding
Biological Process:  actin filament organization; activation of phospholipase C activity; focal adhesion assembly; negative regulation of focal adhesion assembly; negative regulation of stress fiber assembly; positive regulation of GTPase activity; positive regulation of phospholipase activity; regulation of GTPase activity; signal transduction
Reference #:  O54834 (UniProtKB)
Alt. Names/Synonyms: AI504284; Arhgap6; C130038E13; OTTMUSP00000021181; OTTMUSP00000021212; RHG06; Rho GTPase activating protein 6; Rho GTPase-activating protein 6; Rho-type GTPase-activating protein 6; Rho-type GTPase-activating protein RhoGAPX-1; RhoGA; RhoGAPX-1
Gene Symbols: Arhgap6
Molecular weight: 108,844 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
Select Structure to View Below

ARHGAP6

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene