|
ARHGAP6
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: Xp22.2 |
|
Cellular Component:
actin cytoskeleton; actin filament; cytoplasm; cytosol
|
|
Molecular Function:
GTPase activator activity; phospholipase activator activity; phospholipase binding; SH3 domain binding
|
|
Biological Process:
actin filament polymerization; activation of phospholipase C activity; focal adhesion assembly; negative regulation of focal adhesion assembly; negative regulation of stress fiber assembly; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
|
|
Reference #:
O43182
(UniProtKB)
|
|
Alt. Names/Synonyms: ARHGAP6; RHG06; Rho GTPase activating protein 6; Rho GTPase-activating protein 6; Rho-type GTPase-activating protein 6; Rho-type GTPase-activating protein RhoGAPX-1; RHOGAP6; RHOGAPX-1
|
|
Gene Symbols: ARHGAP6
|
|
Molecular weight:
105,947 Da
|
|
Basal Isoelectric point:
7
Predict pI for various phosphorylation states
|
