NAA10 In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, and down-regulates it when induced by hypoxia. Interacts with NAA15, NAA50 and with the ribosome. Binds to MYLK. Ubiquitous. Belongs to the acetyltransferase family. ARD1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation
Chromosomal Location of Human Ortholog: X|X A7.3
Cellular Component:  cytoplasm; cytosol; NatA complex; nucleolus; nucleus
Molecular Function:  N-acetyltransferase activity; peptide alpha-N-acetyltransferase activity; peptide-glutamate-N-acetyltransferase activity; peptide-serine-N-acetyltransferase activity; protein binding; transferase activity; transferase activity, transferring acyl groups
Biological Process:  N-terminal peptidyl-glutamic acid acetylation; N-terminal peptidyl-serine acetylation; N-terminal protein amino acid acetylation; negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric; protein acetylation
Reference #:  Q9QY36 (UniProtKB)
Alt. Names/Synonyms: 2310039H09Rik; alpha-N-acetyltransferase 1A; Ard1; ARD1 homolog A, N-acetyltransferase; Ard1a; N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10; N-acetyltransferase ARD1 homolog; N-alpha-acetyltransferase 10; N-alpha-acetyltransferase 10, NatA catalytic subunit; N-terminal acetyltransferase complex ARD1 subunit homolog A; Naa10; Nalpha acetyltransferase 10; OTTMUSP00000019286; RP23-252M19.3; Te2
Gene Symbols: Naa10
Molecular weight: 26,520 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NAA10

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein