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NAA10
Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX. Acts as a negative regulator of sister chromatid cohesion during mitosis. Belongs to the acetyltransferase family. ARD1 subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation |
| Chromosomal Location of mouse Ortholog: X|X A7.3 |
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Cellular Component:
cytoplasm; cytosol; NatA complex; nucleolus; nucleus
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Molecular Function:
acetyltransferase activity; acyltransferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; N-acetyltransferase activity; peptide alpha-N-acetyltransferase activity; peptide-glutamate-alpha-N-acetyltransferase activity; peptide-serine-alpha-N-acetyltransferase activity; protein binding; ribosome binding; transferase activity
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Biological Process:
N-terminal protein amino acid acetylation; negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric; protein acetylation
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Reference #:
Q9QY36
(UniProtKB)
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Alt. Names/Synonyms: 2310039H09Rik; alpha-N-acetyltransferase 1A; Ard1; ARD1 homolog A, N-acetyltransferase; Ard1a; N(alpha)-acetyltransferase 10, NatA catalytic subunit; N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10; N-acetyltransferase ARD1 homolog; N-alpha-acetyltransferase 10; N-alpha-acetyltransferase 10, NatA catalytic subunit; N-terminal acetyltransferase complex ARD1 subunit homolog A; Naa10; Nalpha acetyltransferase 10; NatA catalytic subunit Naa10; OTTMUSP00000019286; RP23-252M19.3; Te2
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Gene Symbols: Naa10
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Molecular weight:
26,520 Da
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Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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