AOC2 Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. Belongs to the copper/topaquinone oxidase family. Expressed in many tissues with much higher expression in retina. Isoform 1 and isoform 2 are expressed in adipose tissue, whereas isoform 1 only seems to be present in thymus, and isoform 2 only in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase
Chromosomal Location of mouse Ortholog: 11|11 D
Cellular Component:  plasma membrane
Molecular Function:  aliphatic-amine oxidase activity; aminoacetone:oxygen oxidoreductase(deaminating) activity; copper ion binding; metal ion binding; oxidoreductase activity; phenethylamine:oxygen oxidoreductase (deaminating) activity; primary amine oxidase activity; quinone binding; tryptamine:oxygen oxidoreductase (deaminating) activity
Biological Process:  amine metabolic process; catecholamine metabolic process; oxidation-reduction process; visual perception
Reference #:  Q812C9 (UniProtKB)
Alt. Names/Synonyms: Amine oxidase [copper-containing]; amine oxidase, copper containing 2 (retina-specific); Aoc2; OTTMUSP00000002690; RAO; retina-specific amine oxidase; Retina-specific copper amine oxidase
Gene Symbols: Aoc2
Molecular weight: 83,583 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene