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ANXA11
Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis. Belongs to the annexin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis; Nuclear envelope |
| Chromosomal Location of human Ortholog: 10q22.3 |
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Cellular Component:
azurophil granule; cytoplasm; cytosol; melanosome; midbody; nuclear envelope; nucleoplasm; phagocytic vesicle; specific granule; spindle
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Molecular Function:
calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; phosphatidylethanolamine binding; protein binding; S100 protein binding
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Biological Process:
cytokinetic process; phagocytosis; response to calcium ion
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Disease: Amyotrophic Lateral Sclerosis 23; Inclusion Body Myopathy And Brain White Matter Abnormalities
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Reference #:
P50995
(UniProtKB)
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Alt. Names/Synonyms: 56 kDa autoantigen; ALS23; Annexin A11; Annexin XI; Annexin-11; ANX11; anxa 11; ANXA11; autoantigen, 56-kD; Calcyclin-associated annexin 50; CAP-50; CAP50; epididymis secretory sperm binding protein
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Gene Symbols: ANXA11
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Molecular weight:
54,390 Da
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Basal Isoelectric point:
7.53
Predict pI for various phosphorylation states
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