ADSS Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 6.3.4.4; Ligase; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 1q44
Cellular Component:  cytoplasm; cytosol; plasma membrane
Molecular Function:  adenylosuccinate synthase activity; GTP binding; metal ion binding; phosphate binding; protein binding
Biological Process:  AMP biosynthetic process; aspartate metabolic process; immune system process; IMP metabolic process; purine ribonucleoside monophosphate biosynthetic process; response to purine
Reference #:  P30520 (UniProtKB)
Alt. Names/Synonyms: ADEH; adenylosuccinate synthase; adenylosuccinate synthetase (Ade(-)H-complementing); Adenylosuccinate synthetase isozyme 2; Adenylosuccinate synthetase, acidic isozyme; ADSS; AdSS 2; ADSS2; AMPSase 2; IMP--aspartate ligase 2; MGC20404; PURA2
Gene Symbols: ADSS
Molecular weight: 50,097 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
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ADSS

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene