ADORA2B Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 17p12
Cellular Component:  glutamatergic synapse; plasma membrane; presynapse; Schaffer collateral - CA1 synapse
Molecular Function:  G protein-coupled adenosine receptor activity; G protein-coupled receptor activity; protein binding
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to extracellular stimulus; cGMP-mediated signaling; G protein-coupled adenosine receptor signaling pathway; G protein-coupled receptor signaling pathway; mast cell degranulation; positive regulation of cGMP-mediated signaling; positive regulation of chemokine production; positive regulation of chronic inflammatory response to non-antigenic stimulus; positive regulation of guanylate cyclase activity; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of vascular endothelial growth factor production; presynaptic modulation of chemical synaptic transmission; relaxation of vascular associated smooth muscle; vasodilation
Reference #:  P29275 (UniProtKB)
Alt. Names/Synonyms: AA2BR; adenosine A2b receptor; Adenosine receptor A2b; ADORA2; ADORA2B
Gene Symbols: ADORA2B
Molecular weight: 36,333 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene