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ADORA2B
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of Human Ortholog: 17p12 |
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Cellular Component:
glutamatergic synapse; integral component of plasma membrane; plasma membrane; Schaffer collateral - CA1 synapse
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Molecular Function:
G protein-coupled adenosine receptor activity
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Biological Process:
activation of adenylate cyclase activity; activation of MAPK activity; adenosine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular defense response; cellular protein metabolic process; cellular response to extracellular stimulus; excretion; G protein-coupled receptor signaling pathway; JNK cascade; positive regulation of cGMP-mediated signaling; positive regulation of chemokine production; positive regulation of chronic inflammatory response to non-antigenic stimulus; positive regulation of guanylate cyclase activity; positive regulation of interleukin-6 production; positive regulation of mast cell degranulation; positive regulation of vascular endothelial growth factor production; regulation of synaptic vesicle exocytosis; relaxation of vascular smooth muscle
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Reference #:
P29275
(UniProtKB)
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Alt. Names/Synonyms: AA2BR; adenosine A2b receptor; Adenosine receptor A2b; ADORA2; ADORA2B
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Gene Symbols: ADORA2B
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Molecular weight:
36,333 Da
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Basal Isoelectric point:
8.62
Predict pI for various phosphorylation states
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