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ACBD3
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase. (Microbial infection) Sensitizes PI4KB activation by Kobuviral (Aichi) 3A protein. Ubiquitous, with highest expression in testis and ovary. Note: This description may include information from UniProtKB.
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| Chromosomal Location of Human Ortholog: 1 H4|1 84.46 cM |
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Cellular Component:
Golgi apparatus; Golgi membrane; membrane; mitochondrion
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Molecular Function:
fatty-acyl-CoA binding; protein kinase A regulatory subunit binding
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Biological Process:
lipid metabolic process; steroid biosynthetic process
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Reference #:
Q8BMP6
(UniProtKB)
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Alt. Names/Synonyms: 60kDa; 8430407O11Rik; Acbd3; Acyl-CoA-binding domain-containing protein 3; acyl-Coenzyme A binding domain containing 3; D1Ertd10; D1Ertd10e; Gcp60; Goc; GOCAP1; golgi complex associated protein 1, 60 kDa; Golgi complex-associated protein 1; Golgi phosphoprotein 1; Golgi resident protein GCP60; GOLPH1; Pap7; PBR associated protein; PBR- and PKA-associated protein 7; Peripheral benzodiazepine receptor-associated protein PAP7; peripherial benzodiazepine receptor associated protein
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Gene Symbols: Acbd3
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Molecular weight:
60,181 Da
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Basal Isoelectric point:
5.07
Predict pI for various phosphorylation states
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