LRP6 Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. Belongs to the LDLR family. Widely coexpressed with LRP5 during embryogenesis and in adult tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 6 G1|6 65.37 cM
Cellular Component:  caveola; cell surface; cytoplasmic vesicle; early endosome; endoplasmic reticulum; integral component of membrane; membrane; neuronal cell body; plasma membrane; synapse; Wnt signalosome; Wnt-Frizzled-LRP5/6 complex
Molecular Function:  apolipoprotein binding; coreceptor activity involved in Wnt signaling pathway; frizzled binding; identical protein binding; kinase inhibitor activity; low-density lipoprotein particle receptor activity; protein binding; protein homodimerization activity; signaling receptor binding; toxin transmembrane transporter activity; Wnt-activated receptor activity; Wnt-protein binding
Biological Process:  anterior/posterior pattern specification; axis elongation; axis elongation involved in somitogenesis; bone morphogenesis; bone remodeling; branching involved in mammary gland duct morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; cell migration involved in gastrulation; cell-cell adhesion; cellular response to cholesterol; cerebellum morphogenesis; cerebral cortex cell migration; cerebral cortex development; chemical synaptic transmission; convergent extension; dopaminergic neuron differentiation; dorsal/ventral axis specification; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; endocytosis; external genitalia morphogenesis; face morphogenesis; forebrain development; forebrain generation of neurons; forebrain radial glial cell differentiation; formation of radial glial scaffolds; gastrulation with mouth forming second; generation of neurons; heart looping; limb morphogenesis; mammary gland duct morphogenesis; mammary placode formation; midbrain development; midbrain-hindbrain boundary development; morphogenesis of an epithelium; multicellular organism development; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of non-canonical Wnt signaling pathway; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis; negative regulation of planar cell polarity pathway involved in neural tube closure; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest cell differentiation; neural crest formation; neural tube closure; neural tube development; odontogenesis of dentin-containing tooth; pericardium morphogenesis; positive regulation of apoptotic process; positive regulation of bone resorption; positive regulation of cell cycle; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of mesenchymal cell proliferation; positive regulation of neuron projection development; positive regulation of ossification; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; post-anal tail morphogenesis; primitive streak formation; protein localization to plasma membrane; receptor-mediated endocytosis involved in cholesterol transport; regulation of cell development; regulation of cell proliferation; regulation of transcription, DNA-templated; response to folic acid; retina morphogenesis in camera-type eye; roof of mouth development; skeletal system morphogenesis; somitogenesis; thalamus development; trachea cartilage morphogenesis; Wnt signaling pathway; Wnt signaling pathway involved in forebrain neuroblast division; Wnt signaling pathway involved in somitogenesis
Reference #:  O88572 (UniProtKB)
Alt. Names/Synonyms: C030016K15Rik; Cd; crooked; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; LRP-6; Lrp6; OTTMUSP00000023469; ska; ska26; ska<m26J; ska<m26Jus>; skax; skax26
Gene Symbols: Lrp6
Molecular weight: 180,255 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene