WAVE1 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Belongs to the SCAR/WAVE family. Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Cellular Component: 
Reference #:  Q5BJU7 (UniProtKB)
Alt. Names/Synonyms: Actin-binding protein WASF1; Protein WAVE-1; Wasf1; WASP family protein member 1; Wave1; Wiskott-Aldrich syndrome protein family member 1
Gene Symbols: Wasf1
Molecular weight: 61,515 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

WAVE1
Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  GenPept  |  Ensembl Gene  |  Ensembl Protein