NR5A2 Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38. Belongs to the nuclear hormone receptor family. NR5 subfamily. Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: 1 59.98 cM|1 E4
Cellular Component:  cytoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; lipid binding; metal ion binding; nuclear receptor activity; phospholipid binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  bile acid metabolic process; calcineurin-mediated signaling; cellular response to leukemia inhibitory factor; cholesterol homeostasis; epithelial cell differentiation; hormone-mediated signaling pathway; pancreas morphogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of viral genome replication; regulation of cell proliferation; regulation of transcription, DNA-templated; tissue development
Reference #:  P45448 (UniProtKB)
Alt. Names/Synonyms: AU020803; D1Ertd308e; fetoprotein transcription factor; Ftf; Liver receptor homolog 1; LRH-1; Lrh1; Nr5a2; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2
Gene Symbols: Nr5a2
Molecular weight: 64,020 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA