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NR5A2
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38. Belongs to the nuclear hormone receptor family. NR5 subfamily. Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor; Transcription factor |
| Chromosomal Location of mouse Ortholog: 1 59.98 cM|1 E4 |
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Cellular Component:
cytoplasm; cytosol; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; lipid binding; metal ion binding; nuclear receptor activity; phospholipid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding; zinc ion binding
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Biological Process:
acinar cell differentiation; bile acid metabolic process; calcineurin-mediated signaling; cellular response to leukemia inhibitory factor; cholesterol homeostasis; hormone-mediated signaling pathway; pancreas morphogenesis; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of viral genome replication; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; tissue development
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Reference #:
P45448
(UniProtKB)
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Alt. Names/Synonyms: AU020803; D1Ertd308; D1Ertd308e; fetoprotein transcription factor; Ftf; Liver receptor homolog 1; LRH; LRH-1; Lrh1; Nr5a2; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2; UF2-H3B
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Gene Symbols: Nr5a2
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Molecular weight:
64,020 Da
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Basal Isoelectric point:
8.49
Predict pI for various phosphorylation states
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