CK2A1 Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry. Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CK2 family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 20p13
Cellular Component:  cytosol; nucleoplasm; nucleus; NuRD complex; plasma membrane; PML body; protein kinase CK2 complex; Sin3 complex
Molecular Function:  ATP binding; Hsp90 protein binding; identical protein binding; kinase activity; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  apoptotic process; cell cycle; chaperone-mediated protein folding; disruption by symbiont of host cell PML body; negative regulation of apoptotic signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of translation; negative regulation of ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of protein catabolic process; positive regulation of Wnt signaling pathway; protein phosphorylation; protein stabilization; regulation of cell cycle; regulation of chromosome separation; rhythmic process; signal transduction; Wnt signaling pathway
Disease: Okur-chung Neurodevelopmental Syndrome
Reference #:  P68400 (UniProtKB)
Alt. Names/Synonyms: casein kinase 2 alpha 1; casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; Casein kinase II subunit alpha; CK II alpha; CK2 catalytic subunit alpha; CK2A1; Cka1; Cka2; CKII; CSK21; CSNK2A1; OCNDS; protein kinase CK2
Gene Symbols: CSNK2A1
Molecular weight: 45,144 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  NF-kB Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CK2A1

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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein