NR5A2 Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38. Belongs to the nuclear hormone receptor family. NR5 subfamily. Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of human Ortholog: 1q32.1
Cellular Component:  chromatin; cytoplasm; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; phospholipid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding; zinc ion binding
Biological Process:  acinar cell differentiation; bile acid metabolic process; calcineurin-mediated signaling; cellular response to leukemia inhibitory factor; cholesterol homeostasis; embryo development ending in birth or egg hatching; homeostatic process; hormone-mediated signaling pathway; intracellular receptor signaling pathway; pancreas morphogenesis; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; positive regulation of viral genome replication; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; tissue development
Reference #:  O00482 (UniProtKB)
Alt. Names/Synonyms: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; B1F; B1F2; CPF; CYP7A promoter-binding factor; fetoprotein-alpha 1 (AFP) transcription factor; FTF; FTZ-F1; FTZ-F1beta; hB1F; hB1F-2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; liver nuclear receptor homolog-1 variant 2; Liver receptor homolog 1; liver receptor homolog-1; LRH-1; LRH1; NR5A2; nuclear receptor NR5A2; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2
Gene Symbols: NR5A2
Molecular weight: 61,331 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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