GATA3 Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. T-cells and endothelial cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 10p14
Cellular Component:  nuclear chromatin; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; enhancer sequence-specific DNA binding; HMG box domain binding; interleukin-2 receptor binding; protein binding; protein dimerization activity; proximal promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  anatomical structure formation involved in morphogenesis; anatomical structure morphogenesis; aortic valve morphogenesis; axon guidance; blood coagulation; canonical Wnt signaling pathway involved in metanephric kidney development; cardiac right ventricle morphogenesis; cell fate determination; cell maturation; cellular response to BMP stimulus; cellular response to interferon-alpha; cellular response to interleukin-4; cellular response to tumor necrosis factor; chromatin remodeling; cochlea development; cytokine-mediated signaling pathway; defense response; developmental growth; ear development; embryonic hemopoiesis; erythrocyte differentiation; humoral immune response; in utero embryonic development; innate immune response; inner ear morphogenesis; interferon-gamma secretion; interleukin-4 secretion; kidney development; lens development in camera-type eye; lymphocyte migration; male gonad development; mast cell differentiation; mesenchymal to epithelial transition; mesonephros development; negative regulation of cell cycle; negative regulation of cell motility; negative regulation of cell proliferation; negative regulation of cell proliferation involved in mesonephros development; negative regulation of DNA demethylation; negative regulation of endothelial cell apoptotic process; negative regulation of fat cell differentiation; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; negative regulation of inflammatory response; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of mammary gland epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nephric duct formation; nephric duct morphogenesis; neuron migration; norepinephrine biosynthetic process; otic vesicle development; parathyroid gland development; parathyroid hormone secretion; pharyngeal system development; phosphatidylinositol 3-kinase signaling; positive regulation of endothelial cell migration; positive regulation of histone H3-K14 acetylation; positive regulation of histone H3-K9 acetylation; positive regulation of interleukin-13 secretion; positive regulation of interleukin-4 production; positive regulation of interleukin-5 secretion; positive regulation of protein kinase B signaling; positive regulation of signal transduction; positive regulation of T cell differentiation; positive regulation of T-helper 2 cell cytokine production; positive regulation of thyroid hormone generation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; positive regulation of transcription, DNA-templated; positive regulation of ureteric bud formation; post-embryonic development; pro-T cell differentiation; protein deubiquitination; regulation of CD4-positive, alpha-beta T cell differentiation; regulation of cellular response to X-ray; regulation of cytokine biosynthetic process; regulation of establishment of cell polarity; regulation of hematopoietic stem cell differentiation; regulation of histone H3-K27 methylation; regulation of histone H3-K4 methylation; regulation of nephron tubule epithelial cell differentiation; regulation of neuron apoptotic process; regulation of neuron projection development; response to estrogen; response to ethanol; response to gamma radiation; response to virus; signal transduction; sympathetic nervous system development; T cell receptor signaling pathway; T-helper 2 cell differentiation; thymic T cell selection; thymus development; TOR signaling; transcription by RNA polymerase II; type IV hypersensitivity; ureter maturation; ureter morphogenesis; ureteric bud formation; uterus development; ventricular septum development
Disease: Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Reference #:  P23771 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 3; GATA-binding factor 3; GATA3; HDR; HDRS; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3
Gene Symbols: GATA3
Molecular weight: 47,916 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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