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APC2
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. Belongs to the cullin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system |
| Chromosomal Location of mouse Ortholog: 2|2 A3 |
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Cellular Component:
anaphase-promoting complex
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Molecular Function:
ubiquitin protein ligase binding
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Biological Process:
cell cycle; cell differentiation; cell division; metaphase/anaphase transition of mitotic cell cycle; negative regulation of gene expression; nervous system development; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of synapse maturation; positive regulation of synaptic plasticity; protein K11-linked ubiquitination; ubiquitin-dependent protein catabolic process
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Reference #:
Q8BZQ7
(UniProtKB)
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Alt. Names/Synonyms: 9230107K09Rik; AL024279; Anapc2; anaphase promoting complex subunit 2; Anaphase-promoting complex subunit 2; ANC2; APC2; Cyclosome subunit 2; Emi; Emi4; expressed during mesenchymal induction 4; Imi4; induced during mesenchymal induction 4; mKIAA1406; OTTMUSP00000012722
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Gene Symbols: Anapc2
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Molecular weight:
95,307 Da
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Basal Isoelectric point:
5.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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