APC2 Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. Belongs to the cullin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 2|2 A3
Cellular Component:  anaphase-promoting complex; nucleus
Molecular Function:  ubiquitin protein ligase binding
Biological Process:  cell cycle; cell differentiation; cell division; nervous system development; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of synapse maturation; positive regulation of synaptic plasticity; protein K11-linked ubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  Q8BZQ7 (UniProtKB)
Alt. Names/Synonyms: 9230107K09Rik; AL024279; Anapc2; anaphase promoting complex subunit 2; Anaphase-promoting complex subunit 2; ANC2; APC2; Cyclosome subunit 2; Emi; Emi4; expressed during mesenchymal induction 4; Imi4; induced during mesenchymal induction 4; mKIAA1406; OTTMUSP00000012722
Gene Symbols: Anapc2
Molecular weight: 95,307 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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APC2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene