FKBP5 Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Widely expressed, enriched in testis compared to other tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC; Isomerase
Chromosomal Location of Human Ortholog: 17 A3.3|17 14.66 cM
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  FK506 binding; heat shock protein binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding
Biological Process:  chaperone-mediated protein folding; protein peptidyl-prolyl isomerization; response to bacterium
Reference #:  Q64378 (UniProtKB)
Alt. Names/Synonyms: 51 kDa FK506-binding protein; 51 kDa FKBP; 51kDa; D17Ertd592; D17Ertd592e; Dit; Dit1; FK506 binding protein 5; FK506-binding protein 5; FKBP-5; FKBP-51; Fkbp5; Fkbp51; OTTMUSP00000028876; OTTMUSP00000028878; Peptidyl-prolyl cis-trans isomerase FKBP5; PPIase FKBP5; Rotamase
Gene Symbols: Fkbp5
Molecular weight: 50,966 Da
Basal Isoelectric point: 7.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene