NHP2L1 Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Belongs to the eukaryotic ribosomal protein eL8 family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 15 E1|15 38.38 cM
Cellular Component:  box C/D snoRNP complex; dense fibrillar component; nucleolus; nucleus; plasma membrane; protein-containing complex; ribonucleoprotein complex; small-subunit processome; spliceosomal complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; U4atac snRNP
Molecular Function:  ATPase binding; box C/D snoRNA binding; RNA binding; U3 snoRNA binding; U4 snRNA binding; U4atac snRNA binding
Biological Process:  box C/D snoRNP assembly; maturation of LSU-rRNA; mRNA processing; mRNA splicing, via spliceosome; ribosome biogenesis; RNA splicing; single fertilization
Reference #:  Q9D0T1 (UniProtKB)
Alt. Names/Synonyms: FA-1; Fertilization antigen 1; fertilization antigen-1; Fta1; High mobility group-like nuclear protein 2 homolog 1; NH2L1; NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); NHP2-like protein 1; Nhp2l1; sperm specific antigen 1; Sperm-specific antigen 1; Ssfa1; U4/U6.U5 tri-snRNP 15.5 kDa protein
Gene Symbols: Nhp2l1
Molecular weight: 14,174 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene