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PHKG1
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.1; EC 2.7.11.19; EC 2.7.11.26; Kinase, protein; PHK family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 7p11.2 |
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Cellular Component:
cytosol; phosphorylase kinase complex
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Molecular Function:
ATP binding; calmodulin binding; enzyme binding; phosphorylase kinase activity; protein serine kinase activity; tau-protein kinase activity
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Biological Process:
carbohydrate metabolic process; glycogen biosynthetic process; protein phosphorylation
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Reference #:
Q16816
(UniProtKB)
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Alt. Names/Synonyms: PHK-gamma-M; PHKG; PHKG1; Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform; Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; phosphorylase kinase catalytic subunit gamma 1; phosphorylase kinase gamma; phosphorylase kinase gamma subunit 1; Phosphorylase kinase subunit gamma-1; phosphorylase kinase, gamma 1 (muscle); Serine/threonine-protein kinase PHKG1
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Gene Symbols: PHKG1
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Molecular weight:
45,024 Da
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Basal Isoelectric point:
6.4
Predict pI for various phosphorylation states
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