hnRNP A2/B1 Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm. Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion. Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts. Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs. Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs. (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 6|6 B3
Cellular Component:  Cajal body; catalytic step 2 spliceosome; chromatin; chromosome, telomeric region; cytoplasm; extracellular exosome; extracellular region; glutamatergic synapse; neuron projection; neuronal cell body; neuronal ribonucleoprotein granule; nuclear matrix; nucleoplasm; nucleus; perikaryon; postsynaptic cytosol; ribonucleoprotein complex; spliceosomal complex
Molecular Function:  DNA polymerase binding; G-rich strand telomeric DNA binding; identical protein binding; miRNA binding; mRNA 3'-UTR binding; mRNA binding; mRNA CDS binding; N6-methyladenosine-containing RNA binding; nucleic acid binding; pre-mRNA intronic binding; regulatory region RNA binding; RNA binding; single-stranded telomeric DNA binding
Biological Process:  G-quadruplex DNA unwinding; miRNA transport; mRNA export from nucleus; mRNA processing; mRNA splicing, via spliceosome; mRNA transport; negative regulation of mRNA splicing, via spliceosome; negative regulation of transcription by RNA polymerase II; positive regulation of telomerase RNA reverse transcriptase activity; positive regulation of telomere maintenance via telomere lengthening; primary miRNA processing; RNA splicing; RNA transport; telomere capping
Reference #:  O88569 (UniProtKB)
Alt. Names/Synonyms: 9130414A06Rik; heterogeneous nuclear ribonucleoprotein A2/B1; Heterogeneous nuclear ribonucleoproteins A2/B1; heterogenous nuclear ribonucleoprotein A2/B1; hnRNP A2 / hnRNP B1; hnRNP A2/B1; hnrnp-A; Hnrnpa2b1; Hnrp; Hnrpa2; Hnrpa2b1; ROA2
Gene Symbols: Hnrnpa2b1
Molecular weight: 37,403 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Select Structure to View Below

hnRNP A2/B1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene