FASN a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 1.1.1.100; EC 1.3.1.39; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 2.3.1.85; EC 3.1.2.14; EC 4.2.1.59; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase
Chromosomal Location of Human Ortholog: 11 E2|11 84.56 cM
Cellular Component:  cytoplasm; cytosol; glycogen granule; Golgi apparatus; plasma membrane
Molecular Function:  3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; 3-oxo-glutaryl-[acp] methyl ester reductase activity; 3-oxo-pimeloyl-[acp] methyl ester reductase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; acyl-[acyl-carrier-protein] hydrolase activity; catalytic activity; drug binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; fatty acid synthase activity; hydrolase activity; hydrolase activity, acting on ester bonds; identical protein binding; lyase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; NADPH binding; oleoyl-[acyl-carrier-protein] hydrolase activity; oxidoreductase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; phosphopantetheine binding; protein homodimerization activity; transferase activity
Biological Process:  acetyl-CoA metabolic process; biosynthetic process; cell development; cellular response to interleukin-4; establishment of endothelial intestinal barrier; ether lipid biosynthetic process; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; mammary gland development; metabolic process; monocyte differentiation; neutrophil differentiation; oxidation-reduction process; tissue development
Reference #:  P19096 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; A630082H08Rik; Enoyl-[acyl-carrier-protein] reductase; FAS; Fasn; Fatty acid synthase; Oleoyl-[acyl-carrier-protein] hydrolase; OTTMUSP00000004562
Gene Symbols: Fasn
Molecular weight: 272,428 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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FASN

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene