RBCK1 E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. Belongs to the RBR family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 2|2 G3
Cellular Component:  LUBAC complex
Molecular Function:  double-stranded DNA binding; identical protein binding; metal ion binding; protein binding; protein kinase C binding; transferase activity; ubiquitin binding; ubiquitin-protein transferase activity
Biological Process:  negative regulation of necroptotic process; negative regulation of NF-kappaB transcription factor activity; positive regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein linear polyubiquitination; protein polyubiquitination; T cell receptor signaling pathway
Reference #:  Q9WUB0 (UniProtKB)
Alt. Names/Synonyms: AL033326; Heme-oxidized IRP2 ubiquitin ligase 1 homolog; HOI; HOIL-1; HOIL-1L; HOIL1; novel zinc finger, C3HC4 type (RING finger) protein; OTTMUSP00000016877; OTTMUSP00000016878; RanBP-type and C3HC4-type zinc finger containing 1; RanBP-type and C3HC4-type zinc finger-containing protein 1; Rbck; Rbck1; RING-type E3 ubiquitin transferase HOIL-1; RP23-452D3.5; UB7I3; Ubce7i; Ubce7ip3; UbcM4-interacting protein 28; ubiquitin conjugating enzyme 7 interacting protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 3; Uip28
Gene Symbols: Rbck1
Molecular weight: 57,534 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
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RBCK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene