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DOK3
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function. Belongs to the DOK family. Type A subfamily. Expressed in spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 13|13 B1 |
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Cellular Component:
cytoplasm; membrane; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
positive regulation of MAPK cascade; Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q9QZK7
(UniProtKB)
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Alt. Names/Synonyms: AI450713; Docking protein 3; DOK-L; Dok-like protein; Dok3; Dokl; Downstream of tyrosine kinase 3; MGC151299; p62(dok)-like protein; p62Dok-like protein
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Gene Symbols: Dok3
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Molecular weight:
48,027 Da
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Basal Isoelectric point:
6.63
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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