SAHH
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Belongs to the adenosylhomocysteinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid |
Chromosomal Location of mouse Ortholog: 2 H1|2 76.94 cM |
Cellular Component:
cytosol
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Molecular Function:
adenosylhomocysteinase activity; adenyl nucleotide binding; copper ion binding; identical protein binding; NAD binding; protein binding; protein self-association
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Biological Process:
chronic inflammatory response to antigenic stimulus; circadian sleep/wake cycle; response to nutrient; S-adenosylhomocysteine catabolic process; S-adenosylmethionine cycle
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Reference #:
P50247
(UniProtKB)
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Alt. Names/Synonyms: AA987153; Adenosylhomocysteinase; AdoHcyase; Ahcy; AL024110; CuB; CUBP; Liver copper-binding protein; MGC102079; MGC118063; MGC19228; OTTMUSP00000017088; S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase; SAHH
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Gene Symbols: Ahcy
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Molecular weight:
47,688 Da
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Basal Isoelectric point:
6.08
Predict pI for various phosphorylation states
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