SAHH Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Belongs to the adenosylhomocysteinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC; Hydrolase; Other Amino Acids Metabolism - selenoamino acid
Chromosomal Location of mouse Ortholog: 2 H1|2 76.94 cM
Cellular Component:  cytosol
Molecular Function:  adenosylhomocysteinase activity; adenyl nucleotide binding; copper ion binding; identical protein binding; NAD binding; protein binding; protein self-association
Biological Process:  chronic inflammatory response to antigenic stimulus; circadian sleep/wake cycle; response to nutrient; S-adenosylhomocysteine catabolic process; S-adenosylmethionine cycle
Reference #:  P50247 (UniProtKB)
Alt. Names/Synonyms: AA987153; Adenosylhomocysteinase; AdoHcyase; Ahcy; AL024110; CuB; CUBP; Liver copper-binding protein; MGC102079; MGC118063; MGC19228; OTTMUSP00000017088; S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase; SAHH
Gene Symbols: Ahcy
Molecular weight: 47,688 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein