ELK1 Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation. Belongs to the ETS family. Lung and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of rat Ortholog: Xq11
Cellular Component:  axon terminus; cytoplasm; dendrite; mitochondrion; neuronal cell body; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; nuclear receptor coactivator activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding
Biological Process:  cell differentiation; cellular response to gamma radiation; cellular response to lipid; cellular response to testosterone stimulus; DNA-templated transcription elongation; gene expression; liver development; lung development; positive regulation of DNA-templated transcription; positive regulation of neuron death; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to fibroblast growth factor; response to light stimulus
Reference #:  A4GTP4 (UniProtKB)
Alt. Names/Synonyms: Elk1; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1
Gene Symbols: Elk1
Molecular weight: 45,272 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ELK1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein