CASP1
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly. Belongs to the peptidase C14A family. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 3.4.22.36; Protease
Chromosomal Location of human Ortholog: 11q22.3
Cellular Component:
AIM2 inflammasome complex; canonical inflammasome complex; cytoplasm; cytosol; IPAF inflammasome complex; microtubule; NLRP1 inflammasome complex; NLRP3 inflammasome complex; nucleolus; plasma membrane; protease inhibitor complex; protein-containing complex
Molecular Function:
CARD domain binding; caspase binding; cysteine-type endopeptidase activator activity involved in apoptotic process; cysteine-type endopeptidase activity; endopeptidase activity; identical protein binding; kinase binding; protein binding
Biological Process:
AIM2 inflammasome complex assembly; apoptotic process; cellular response to lipopolysaccharide; cellular response to mechanical stimulus; cellular response to organic substance; cellular response to type II interferon; cytokine precursor processing; defense response to bacterium; defense response to virus; icosanoid biosynthetic process; osmosensory signaling pathway; pattern recognition receptor signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of interleukin-1 beta production; positive regulation of interleukin-18 production; positive regulation of tumor necrosis factor-mediated signaling pathway; protein autoprocessing; protein maturation; proteolysis; pyroptosis; regulation of apoptotic process; regulation of inflammatory response; signal transduction; signaling receptor ligand precursor processing
Reference #:
P29466
(UniProtKB)
Alt. Names/Synonyms: CASP-1; CASP1; CASP1 nirs variant 1; Caspase 1; caspase 1, apoptosis-related cysteine peptidase; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase); Caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; caspase1; Caspase1; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; IL1BC; IL1BCE; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; interleukin 1-beta convertase; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
Gene Symbols: CASP1
Molecular weight:
45,159 Da
Basal Isoelectric point:
5.63
Predict pI for various phosphorylation states
CST Pathways:
ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
Select Structure to View Below
CASP1
1BMQ - A=131-297, B=317-404 (human)
1IBC - A=104-297, B=317-404 (human)
1ICE - A=131-297, B=317-404 (human)
1RWK - A=120-297, B=317-404 (human)
1RWM - A=120-297, B=317-404 (human)
1RWN - A=120-297, B=317-404 (human)
1RWO - A=120-297, B=317-404 (human)
1RWP - A=120-297, B=317-404 (human)
1RWV - A=120-297, B=317-404 (human)
1RWW - A=120-297, B=317-404 (human)
1RWX - A=120-297, B=317-404 (human)
1SC1 - A=120-297, B=317-404 (human)
1SC3 - A=120-297, B=317-404 (human)
1SC4 - A=120-297, B=317-404 (human)
2FQQ - A=120-297, B=317-404 (human)
2H48 - A=120-297, B=317-404 (human)
2H4W - A=120-297 B=317-404 (human)
2H4Y - A=120-297 B=317-404 (human)
2H51 - A=120-297 B=317-404 (human)
2H54 - A=120-297 B=317-404 (human)
2HBQ - A=120-297, B=317-404 (human)
2HBR - A=120-297, B=317-404 (human)
2HBY - A=120-297, B=317-404 (human)
2HBZ - A=120-297, B=317-404 (human)
3D6F - A=120-297 B=317-404 (human)
3D6H - A=120-297 B=317-404 (human)
3D6M - A=120-297 B=317-404 (human)
3E4C - A/B=104-404 (human)
3NS7 - A=136-297 B=317-404 (human)
5FNA - F/A/E/B/H/C/D/G=2-86 (human)
5MMV - A=120-297 B=317-404 (human)
5MTK - A=120-297 B=317-404 (human)
6BZ9 - A=120-297 B=317-404 (human)
6F6R - A=118-297 B=317-404 (human)
6KN0 - F/E=283-480 (human)
6PZP - A=120-297 B=317-404 (human)
6VIE - D/C=1-487 (human)
7KEU - A/D/C/B=113-194 (human)
8SV1 - C/c=6-193 (human)
8WRA - A=120-404 (human)