TESK2 Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TESK subfamily; TKL group
Chromosomal Location of Human Ortholog: 5q35
Cellular Component:  cytoplasm; nuclear body; nucleoplasm; nucleus
Molecular Function:  ATP binding; metal ion binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process:  actin cytoskeleton organization; apoptotic process; focal adhesion assembly; intracellular signal transduction; peptidyl-tyrosine phosphorylation; protein phosphorylation; spermatogenesis
Reference #:  Q924U5 (UniProtKB)
Alt. Names/Synonyms: Dual specificity testis-specific protein kinase 2; Tesk2; Testicular protein kinase 2; testis-specific kinase 2
Gene Symbols: Tesk2
Molecular weight: 63,559 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene