EHMT2 Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; EC; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of mouse Ortholog: 17 B1|17 18.45 cM
Cellular Component:  chromosome; nuclear chromatin; nuclear speck; nucleoplasm; nucleus
Molecular Function:  C2H2 zinc finger domain binding; histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; p53 binding; promoter-specific chromatin binding; protein binding; protein-lysine N-methyltransferase activity; RNA polymerase II regulatory region sequence-specific DNA binding; transferase activity; zinc ion binding
Biological Process:  behavioral response to cocaine; cellular response to cocaine; cellular response to drug; cellular response to starvation; chromatin organization; DNA methylation; DNA methylation on cytosine within a CG sequence; fertilization; germ cell development; histone H3-K27 methylation; histone H3-K9 methylation; histone lysine methylation; histone methylation; long-term memory; methylation; negative regulation of autophagosome assembly; negative regulation of transcription by RNA polymerase II; neuron fate specification; organ growth; peptidyl-lysine dimethylation; phenotypic switching; regulation of DNA methylation; regulation of DNA replication; regulation of histone H3-K4 methylation; regulation of histone H3-K9 methylation; regulation of transcription by RNA polymerase II; spermatid development; synaptonemal complex assembly
Reference #:  Q9Z148 (UniProtKB)
Alt. Names/Synonyms: Bat; Bat8; D17Ertd710; D17Ertd710e; Ehmt2; euchromatic histone lysine N-methyltransferase 2; Euchromatic histone-lysine N-methyltransferase 2; G9a; H3-K9-HMTase 3; Histone H3-K9 methyltransferase 3; Histone-lysine N-methyltransferase EHMT2; Histone-lysine N-methyltransferase, H3 lysine-9 specific 3; HLA-B associated transcript 8; HLA-B-associated transcript 8; KMT1C; NG3; Ng36; OTTMUSP00000017486; OTTMUSP00000017488; Protein G9a
Gene Symbols: Ehmt2
Molecular weight: 138,039 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene