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DHPS
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Belongs to the deoxyhypusine synthase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 2.5.1.46; Transferase |
| Chromosomal Location of mouse Ortholog: 8|8 C3 |
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Cellular Component:
cytoplasm
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Molecular Function:
deoxyhypusine synthase activity; identical protein binding; transferase activity
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Biological Process:
glucose homeostasis; peptidyl-lysine modification to peptidyl-hypusine; positive regulation of T cell proliferation; protein homotetramerization; spermidine catabolic process; spermidine metabolic process
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Reference #:
Q3TXU5
(UniProtKB)
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Alt. Names/Synonyms: Deoxyhypusine synthase; Dhps; Dhs; DHYS; MGC49129; MGC74384
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Gene Symbols: Dhps
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Molecular weight:
40,642 Da
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Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
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