DHPS Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. Belongs to the deoxyhypusine synthase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC; Transferase
Chromosomal Location of mouse Ortholog: 8|8 C3
Cellular Component:  cytoplasm
Molecular Function:  deoxyhypusine synthase activity; identical protein binding; transferase activity
Biological Process:  glucose homeostasis; peptidyl-lysine modification to peptidyl-hypusine; positive regulation of T cell proliferation; protein homotetramerization; spermidine catabolic process; spermidine metabolic process
Reference #:  Q3TXU5 (UniProtKB)
Alt. Names/Synonyms: Deoxyhypusine synthase; Dhps; Dhs; DHYS; MGC49129; MGC74384
Gene Symbols: Dhps
Molecular weight: 40,642 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein