DCK Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Chromosomal Location of mouse Ortholog: 5|5 E1
Cellular Component:  cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus
Molecular Function:  ATP binding; cytidine kinase activity; deoxyadenosine kinase activity; deoxycytidine kinase activity; deoxyguanosine kinase activity; deoxynucleoside kinase activity; deoxyribonucleoside binding; kinase activity; magnesium ion binding; nucleotide binding; protein homodimerization activity; pyrimidine deoxyribonucleoside binding; transferase activity
Biological Process:  dAMP salvage; deoxycytidine metabolic process; deoxyribonucleoside monophosphate biosynthetic process; dGMP salvage; nucleobase-containing compound metabolic process; nucleoside phosphate biosynthetic process; nucleotide biosynthetic process; phosphorylation; pyrimidine nucleotide metabolic process
Reference #:  P43346 (UniProtKB)
Alt. Names/Synonyms: Dck; Deoxyadenosine kinase; Deoxycytidine kinase; Deoxyguanosine kinase; OTTMUSP00000030586
Gene Symbols: Dck
Molecular weight: 30,367 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DCK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein