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STAT6
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Belongs to the transcription factor STAT family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of rat Ortholog: 7q22 |
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Cellular Component:
chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator binding
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Biological Process:
cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cytokine-mediated signaling pathway; defense response; gene expression; growth hormone receptor signaling pathway via JAK-STAT; interleukin-4-mediated signaling pathway; isotype switching to IgE isotypes; mammary gland epithelial cell proliferation; mammary gland morphogenesis; negative regulation of complement-dependent cytotoxicity; negative regulation of transcription by RNA polymerase II; negative regulation of type 2 immune response; positive regulation of cold-induced thermogenesis; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of mast cell proliferation; regulation of transcription by RNA polymerase II; response to cytokine; response to peptide hormone; signal transduction; T-helper 1 cell lineage commitment
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Reference #:
NP_001037715
(RefSeq)
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Alt. Names/Synonyms: Signal transducer and activator of transcription; signal transducer and activator of transcription 6; STAT6
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Gene Symbols: Stat6
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Molecular weight:
93,870 Da
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Basal Isoelectric point:
6.01
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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