TIPRL
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. Belongs to the TIP41 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Unknown function |
Chromosomal Location of human Ortholog: 1q24.2 |
Cellular Component:
cytosol
|
Molecular Function:
protein binding
|
Biological Process:
DNA damage checkpoint signaling; negative regulation of phosphoprotein phosphatase activity; regulation of phosphoprotein phosphatase activity; TOR signaling
|
Reference #:
O75663
(UniProtKB)
|
Alt. Names/Synonyms: CG9578-like; dJ69E11.3; MGC3794; putative MAPK activating protein; Putative MAPK-activating protein PM10; TIP; TIP41; TIP41, TOR signaling pathway regulator-like; TIP41, TOR signaling pathway regulator-like (S. cerevisiae); TIP41, TOR signalling pathway regulator-like; TIP41-like protein; TIPRL; TIPRL1; TOR signaling pathway regulator; Type 2A-interacting protein; yeast YPR037W and worm C02C2.6 predicted proteins-like
|
Gene Symbols: TIPRL
|
Molecular weight:
31,444 Da
|
Basal Isoelectric point:
5.6
Predict pI for various phosphorylation states
|