ZNF219 Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3'. Binds to the HMGN1 promoter and may repress HMGN1 expression. Regulates SNCA expression in primary cortical neurons. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9. Plays a role in chondrocyte differentiation. Belongs to the krueppel C2H2-type zinc-finger protein family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component:  integral component of membrane; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; histamine receptor activity; metal ion binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  G protein-coupled receptor signaling pathway; limb bud formation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of chondrocyte differentiation; positive regulation of transcription by RNA polymerase II; regulation of neurotransmitter levels; regulation of transcription, DNA-templated; transcription, DNA-templated
Reference #:  Q9P2Y4 (UniProtKB)
Alt. Names/Synonyms: ZFP219; Zinc finger protein 219; ZN219; ZNF219
Gene Symbols: ZNF219
Molecular weight: 76,877 Da
Basal Isoelectric point: 9.56  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein