ATIC Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. Belongs to the PurH family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.3; EC 3.5.4.10; Hydrolase; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 1|1 C3
Cellular Component:  cytosol; plasma membrane
Molecular Function:  catalytic activity; hydrolase activity; IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; protein homodimerization activity; transferase activity
Biological Process:  'de novo' IMP biosynthetic process; cellular response to interleukin-7; dihydrofolate metabolic process; metabolic process; nucleoside metabolic process; purine nucleotide biosynthetic process; ribonucleotide metabolic process; tetrahydrofolate biosynthetic process
Reference #:  Q9CWJ9 (UniProtKB)
Alt. Names/Synonyms: 2610509C24Rik; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; AA536954; AICAR transformylase; ATIC; AW212393; Bifunctional purine biosynthesis protein PURH; IMP cyclohydrolase; IMP synthase; Inosinicase; Phosphoribosylaminoimidazolecarboxamide formyltransferase; PUR9; Purh
Gene Symbols: Atic
Molecular weight: 64,217 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
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ATIC

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene