ATIC Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. Belongs to the PurH family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.3; EC 3.5.4.10; Hydrolase; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of human Ortholog: 2q35
Cellular Component:  cytosol; plasma membrane
Molecular Function:  IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; protein homodimerization activity
Biological Process:  'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; 'de novo' XMP biosynthetic process; animal organ regeneration; brainstem development; cellular response to interleukin-7; cerebellum development; cerebral cortex development; dihydrofolate metabolic process; GMP biosynthetic process; nucleobase-containing compound metabolic process; response to inorganic substance; tetrahydrofolate biosynthetic process
Disease: Aicar Transformylase/imp Cyclohydrolase Deficiency
Reference #:  P31939 (UniProtKB)
Alt. Names/Synonyms: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR; AICAR formyltransferase; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase; AICAR transformylase/inosine monophosphate cyclohydrolase; AICARFT; AICARFT/IMPCHASE; ATIC; Bifunctional purine biosynthesis protein ATIC; Bifunctional purine biosynthesis protein ATIC, N-terminally processed; Bifunctional purine biosynthesis protein PURH; epididymis secretory sperm binding protein Li 70p; FLJ93545; HEL-S-70p; IMP cyclohydrolase; IMP synthase; IMPCHASE; Inosine 5'-monophosphate cyclohydrolase; Inosinicase; Phosphoribosylaminoimidazolecarboxamide formyltransferase; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PUR9; PURH
Gene Symbols: ATIC
Molecular weight: 64,616 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
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ATIC

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein