ATIC Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. Belongs to the PurH family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; EC; Hydrolase; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 2q35
Cellular Component:  cytosol; plasma membrane
Molecular Function:  IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; protein homodimerization activity
Biological Process:  'de novo' IMP biosynthetic process; animal organ regeneration; brainstem development; cellular response to interleukin-7; cerebellum development; cerebral cortex development; dihydrofolate metabolic process; nucleobase-containing compound metabolic process; nucleoside metabolic process; purine ribonucleoside monophosphate biosynthetic process; response to inorganic substance; tetrahydrofolate biosynthetic process
Disease: Aicar Transformylase/imp Cyclohydrolase Deficiency
Reference #:  P31939 (UniProtKB)
Alt. Names/Synonyms: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase; AICARFT; AICARFT/IMPCHASE; ATIC; Bifunctional purine biosynthesis protein PURH; FLJ93545; IMP cyclohydrolase; IMP synthase; IMPCHASE; Inosinicase; Phosphoribosylaminoimidazolecarboxamide formyltransferase; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PUR9; PURH
Gene Symbols: ATIC
Molecular weight: 64,616 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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