PSMA7 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. Belongs to the peptidase T1A family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 2|2 H4
Cellular Component:  cytoplasm; nucleus; postsynapse; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex
Molecular Function:  endopeptidase activity; hydrolase activity; identical protein binding; peptidase activity; threonine-type endopeptidase activity
Biological Process:  proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; proteolysis; proteolysis involved in cellular protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  Q9Z2U0 (UniProtKB)
Alt. Names/Synonyms: C6-I; OTTMUSP00000017387; proteasome (prosome, macropain) subunit, alpha type 7; Proteasome subunit alpha type-7; Proteasome subunit RC6-1; PSA7; Psma7
Gene Symbols: Psma7
Molecular weight: 27,855 Da
Basal Isoelectric point: 8.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene