PSMA7 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response. Belongs to the peptidase T1A family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.25.1; Protease; Proteasome complex
Chromosomal Location of human Ortholog: 20q13.33
Cellular Component:  cytosol; nucleoplasm; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex
Molecular Function:  identical protein binding; protein binding; threonine-type endopeptidase activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mitotic cell cycle phase transition; regulation of mRNA stability; regulation of transcription from RNA polymerase II promoter in response to hypoxia; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; viral process; Wnt signaling pathway, planar cell polarity pathway
Reference #:  O14818 (UniProtKB)
Alt. Names/Synonyms: C6; epididymis secretory protein Li 276; HEL-S-276; HSPC; MGC3755; proteasome (prosome, macropain) subunit, alpha type, 7; proteasome 20S subunit alpha 7; proteasome subunit alpha 4; proteasome subunit alpha 7; Proteasome subunit alpha type-7; Proteasome subunit RC6-1; Proteasome subunit XAPC7; PSA7; PSMA7; RC6-1; testicular tissue protein Li 151; XAPC7
Gene Symbols: PSMA7
Molecular weight: 27,887 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
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PSMA7

Protein Structure Not Found.


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