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RRM1
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Belongs to the ribonucleoside diphosphate reductase large chain family. Note: This description may include information from UniProtKB.
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| Protein type: DNA replication; EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 7 E3|7 54.72 cM |
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Cellular Component:
cell projection; cytoplasm; cytosol; neuronal cell body; nuclear envelope; ribonucleoside-diphosphate reductase complex
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Molecular Function:
ATP binding; catalytic activity; disordered domain specific binding; identical protein binding; nucleotide binding; oxidoreductase activity; protein binding; purine nucleotide binding; ribonucleoside-diphosphate reductase activity; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
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Biological Process:
2'-deoxyribonucleotide biosynthetic process; deoxyribonucleotide biosynthetic process; DNA repair; DNA replication; DNA synthesis involved in DNA repair; metabolic process; mitochondrial DNA replication; positive regulation of G0 to G1 transition; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; protein heterotetramerization; ribonucleoside diphosphate metabolic process
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Reference #:
P07742
(UniProtKB)
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Alt. Names/Synonyms: Ribonucleoside-diphosphate reductase large subunit; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit; ribonucleotide reductase M1; RIR1; RnrM1; Rrm1
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Gene Symbols: Rrm1
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Molecular weight:
90,210 Da
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Basal Isoelectric point:
6.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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