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ALG1
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.142; Endoplasmic reticulum; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane
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Molecular Function:
chitobiosyldiphosphodolichol beta-mannosyltransferase activity; mannosyltransferase activity
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Biological Process:
dolichol-linked oligosaccharide biosynthetic process; mannosylation; protein glycosylation
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Disease: Congenital Disorder Of Glycosylation, Type Ik
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Reference #:
Q9BT22
(UniProtKB)
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Alt. Names/Synonyms: ALG1; ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase; asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog; asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae); Asparagine-linked glycosylation protein 1 homolog; beta-1,4 mannosyltransferase; Beta-1,4-mannosyltransferase; CDG1K; Chitobiosyldiphosphodolichol beta-mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; hMat-1; HMAT1; HMT-1; HMT1; Mannosyltransferase-1; Mat-1; MT-1
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Gene Symbols: ALG1
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Molecular weight:
52,518 Da
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Basal Isoelectric point:
6.8
Predict pI for various phosphorylation states
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