ALG1 Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Endoplasmic reticulum; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of human Ortholog: 16p13.3
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function:  chitobiosyldiphosphodolichol beta-mannosyltransferase activity; mannosyltransferase activity
Biological Process:  dolichol-linked oligosaccharide biosynthetic process; mannosylation; protein glycosylation
Disease: Congenital Disorder Of Glycosylation, Type Ik
Reference #:  Q9BT22 (UniProtKB)
Alt. Names/Synonyms: ALG1; ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase; asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog; asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae); Asparagine-linked glycosylation protein 1 homolog; beta-1,4 mannosyltransferase; Beta-1,4-mannosyltransferase; CDG1K; Chitobiosyldiphosphodolichol beta-mannosyltransferase; GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase; GDP-mannose-dolichol diphosphochitobiose mannosyltransferase; hMat-1; HMAT1; HMT-1; HMT1; Mannosyltransferase-1; Mat-1; MT-1
Gene Symbols: ALG1
Molecular weight: 52,518 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene