KLK7 May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Belongs to the peptidase S1 family. Kallikrein subfamily. Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.35; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 19q13.41
Cellular Component:  epidermal lamellar body; extracellular region; extracellular space
Molecular Function:  peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  epidermis development; extracellular matrix disassembly; positive regulation of antibacterial peptide production; proteolysis
Reference #:  P49862 (UniProtKB)
Alt. Names/Synonyms: hK7; hSCCE; kallikrein 7 (chymotryptic, stratum corneum); kallikrein related peptidase 7; Kallikrein-7; kallikrein-related peptidase 7; KLK7; protease, serine, 6; PRSS6; SCCE; Serine protease 6; signal protein; Stratum corneum chymotryptic enzyme
Gene Symbols: KLK7
Molecular weight: 27,525 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
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KLK7

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene